CHITA – a registry of in vitro NAMs
Faster adoption of alternatives to animals in biomedical research is a worthy goal for both scientific and ethical reasons. Addressing key elements of technology readiness for cell-based alternatives (in vitro…
It’s not just about measuring what matters – it’s about making what you measure matter. There are many options for endpoints to measure in phenotypic assays. Endpoints to consider include…
Developing phenotypic assays that model human disease is a heavy lift. Our understanding of disease biology is limited. And there are so many variables, it’s hard to know where to…
How do we design phenotypic assays that are physiologically relevant? And what do we mean by “relevant”? For those of us working in drug discovery or chemical safety, what we…
When I started out in tissue culture of primary human cells, there were few methods available and few options for cell types. Most human cell-based assays used immortalized cell lines…
