CHITA – a registry of in vitro NAMs
If we want to replace animal testing in biomedical research, how do we find human-relevant alternatives? It’s not that simple. There are 1000s of human cell-based assays and systems that…
The ToxCast program (Toxicity Forecaster) is a long running research program at the US EPA that has been steadily supporting alternatives to animals since 2007. The ToxCast program has generated…
A recent paper from NTP showcases the application of mechanism-based NAMs for prediction of cardiotoxic potential. In a previous post, Getting Back on Track with NAMs at FDA, we encouraged…
Excipients are the “fillers” in formulated drugs. They are included to ensure long term storage, stabilize or promote delivery of the active drug. Excipients are assumed by many to be…
The ToxCast program of the US EPA was initiated over a decade ago. Its goal was to find rapid and efficient methods to prioritize thousands of chemicals for potential human health…
Many drugs can cause adverse effects on the cardiovascular system. Oncology drugs including targeted kinase inhibitors are particularly problematic. Cardiovascular toxicities present in the clinic as high blood pressure, cardiac…
