Mechanisms of Cardiovascular Disease and Toxicity

Cardiovascular toxicities (CV) are adverse drug reactions (ADRs) that affect the heart and vascular system. These toxicities present as high blood pressure, cardiac arrhythmias, heart…

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Phenotypic Profiling to Support Chemical Safety

Chemicals can cause toxicity in people through diverse mechanisms. Unfortunately, most of these mechanisms are unknown. Furthermore, animal testing does not predict the toxicity of…

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Unexpected Bioactivities of Drug Excipients

Excipients are major components of formulated drugs. These are materials included to promote stability or to control the bioavailability of active drug substances. They are…

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Assay Validation Using Chemical Probes

Exploring Target Function Using Chemical Probes in Phenotypic Assays Chemical probes are small molecules that interact with specific targets. Characterizing phenotypic assays with chemical probes…

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