CHITA – a registry of in vitro NAMs
Incorporating more relevant, human-based approaches (in vitro and in silico) in biomedical and toxicological research is a hot topic these days (see recent conferences organized by SOT, BioMed21, WC10, SACATM,…
In drug discovery and chemical safety research, validation lies at the heart of every assay, reagent and experiment. Validation is fundamental for life sciences research effectiveness and, according to Scannell and…
The recent re-launch of the Chemical Probes Portal, a community-led resource for chemical probe information, is a convenient time for reviewing best practices. Chemical probes are small molecules developed to selectively…
If phenotypic screening is driving innovation in drug discovery, network biology is the fuel. In phenotypic screening, compounds are tested for their functional effects on cellular responses in a target agnostic…
The selection of chemical matter to be used for screening is a major discussion topic for phenotypic drug discovery (PDD) researchers. At the recent Keystone Symposium on PDD, several talks were…
We are scientists interested in predictive human biology. We believe in the promise that in vitro data can help predict human responses to environmental and drug exposures. We think that…
